Arginine side-chain modification that occurs during copper-catalysed azide-alkyne click reactions resembles an advanced glycation end product.

نویسندگان

  • Anne C Conibear
  • Karine Farbiarz
  • Rupert L Mayer
  • Maria Matveenko
  • Hanspeter Kählig
  • Christian F W Becker
چکیده

Dehydroascorbate is a by-product of copper-catalysed azide-alkyne click (CuAAC) reactions and also forms advanced glycation end products (AGEs) in tissues undergoing oxidative stress. Here we isolate and characterize an arginine-dehydroascorbate adduct formed during CuAAC reactions, investigate strategies for preventing its formation, and propose its biological relevance as an AGE.

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عنوان ژورنال:
  • Organic & biomolecular chemistry

دوره 14 26  شماره 

صفحات  -

تاریخ انتشار 2016